成果報告
1) Kitamura T, Iwami T, Atsumi T, Endo T, Kanna T, Kuroda Y, Sakurai A, Tasaki O,
Tahara Y, Tsuruta R, Tomio J, Nakata K, Nachi S, Hase M, Hayakawa M, Hiruma T, Hiasa
K, Muguruma T, Yano T, Shimazu Y, Morimura N; the special committee that aims to
improve the survival after out-of-hospital cardiac arrest (OHCA) by providing evidence-
based therapeutic strategy and emergency medical system from the Japanese Association
for Acute Medicine (JAAM). The profile of Japanese Association for Acute Medicine –
out-of-hospital cardiac arrest registry in 2014-2015. Acute Medicine & Surgery
2018;5(3):249-258. IF1.6 10.1002/ams2.340
2) Irisawa T, Matsuyama T, Iwami T, Yamada T, Hayakawa K, Yoshiya K, Noguchi K,
Nishimura T, Uejima T, Yagi Y, Kiguchi T, Kishimoto M, Matsuura M, Hayashi Y, Sogabe
T, Morooka T, Kitamura T, Shimazu T, for the CRITICAL Study investigators. The effect
of different target temperatures in targeted temperature management on neurologically
favorable outcome after out-of-hospital cardiac arrest: a nationwide multicenter
observational study in Japan (the JAAM-OHCA registry). Resuscitation
2018;133(12):82-87. IF6.5 10.1016/j.resuscitation.2018.10.004
3) Kaneda K, Yagi T, Todani M, Nakahara T, Fujita M, Kawamura Y, Oda Y, Tsuruta
R. Impact of type of emergency department on the outcome of out‐of‐hospital cardiac
arrest: a prospective cohort study. Acute Medicine & Surgery 2019;6(4):371-378. IF1.6
10.1002/ams2.423
4) Nishikimi M, Ogura T, Nishida K, Takahashi K, Nakamura M, Matsui S, Matsuda
N, Iwami T. External validation of a risk classification at the emergency department of
post-cardiac arrest syndrome patients undergoing targeted temperature management.
Resuscitation 2019;140(7):135-142. IF6.5 10.1016/j.resuscitation.2019.05.028
5) Okazaki T, Hifumi T, Kawakita K, Kuroda Y, Targeted temperature management
guided by the severity of hyperlactatemia for out-of-hospital cardiac arrest patients: a post
hoc analysis of a nationwide, multicenter prospective registry. Annals of Intensive Care
2019;9:1. IF8.1 10.1186/s13613-019-0603-y
6) Koyama S, Gibo K, Yamaguchi Y, Okubo M. Variation in survival after out-of-hospital cardiac arrest between receiving hospitals in Japan: an observational study. BMJ Open
2019;9:e033919. IF2.9 10.1136/bmjopen-2019-033919
7) Kandori K, Okada Y, Okada A, Nakajima S, Okada N, Matsuyama T, Kitamura T,
Narumiya H, Iizuka R. Association between cardiac rhythm conversion and neurological
outcome among cardiac arrest patients with initial shockable rhythm: a nationwide,
multicenter prospective study in Japan. European Heart Journal: Acute Cardiovascular
Care 2020;10(2):119-126. IF4.1 10.1093/ehjacc/zuaa018
8) Okada Y, Kiguchi T, Irisawa T, Yoshiya K, Yamada T, Hayakawa K, Noguchi K,
Nishimura T, Ishibe T, Yagi Y, Kishimoto M, Shintani H, Hayashi Y, Sogabe T, Morooka
T, Sakamoto H, Suzuki K, Nakamura F, Nishioka N, Matsuyama T, Matsui S, Shimazu T,
Koike K, Kawamura T, Kitamura T, Iwami T. Predictive accuracy of biomarkers for
survival among cardiac arrest patients with hypothermia: a prospective observational
cohort study in Japan. Scandinavian Journal of Trauma, Resuscitation and Emergency
Medicine 2020;28:75. IF3.3 10.1186/s13049-020-00765-2
9) Kitada M, Kaneko T, Yamada S, Harada M, Takahashi T. Extracorporeal
cardiopulmonary resuscitation without target temperature management for out-of-
hospital cardiac arrest patients prolongs the therapeutic time window: a retrospective
analysis of a nationwide multicentre observational study in Japan, Journal of Intensive
Care 2020:8:58. IF7.1 10.1186/s40560-020-00478-9
10) Okada Y, Kiguchi T, Irisawa T, Yamada T, Yoshiya K, Park C, Nishimura T,
Ishibe T, Yagi Y, Kishimoto M, Inoue T, Hayashi Y, Sogabe T, Morooka T, Sakamoto
H, Suzuki K, Nakamura F, Matsuyama T, Nishioka N, Kobayashi D, Matsui S,
Hirayama A, Yoshimura S, Kimata S, Shimazu T, Ohtsuru S, Kitamura T, Iwami T,
on behalf of the CRITICAL Research Group Investigators. Development and
validation of a clinical score to predict neurologic outcome in patients with out-of-
hospital cardiac arrest treated with extracorporeal cardiopulmonary resuscitation.
JAMA Network Open 2020;3(11):e2022920. IF13.1
10.1001/jamanetworkopen.2020.22920
11) Hatakeyama T, Kiguchi T, Sera T, Nachi S, Ochiai K, Kitamura T, Ogura S, Otomo
Y, Iwami T. Pre-hospital physician’s presence and neurological outcome among patients
with out-of-hospital cardiac arrest: a nationwide multicenter observational study in Japan (the JAAM-OHCA Registry). Resuscitation 2021:167(10):38-46. IF6.5
10.1016/j.resuscitation.2021.08.010
12) Yasuda Y, Nishikimi M, Matsui K, Numaguchi A, Nishida K, Emoto R, Matsui
S, Matsuda N. The rCAST score is useful for estimating the neurological prognosis in
pediatric patients with post-cardiac arrest syndrome before ICU admission: External
validation study using a nationwide prospective registry. Resuscitation
2021;168(11):103-109, IF6.5 10.1016/j.resuscitation.2021.09.025
13) Yamada S, Kaneko T, Kitada M, Harada M, Takahashi T. Shorter interval from
witnessed out-of-hospital cardiac arrest to reaching the target temperature could improve
neurological outcomes after extracorporeal cardiopulmonary resuscitation with target
temperature management: A retrospective analysis of a Japanese nationwide multicenter
observational registry, Therapeutic Hypothermia and Temperature Management
2021;11(3):185-191. IF1.2 10.1089/ther.2020.0045
14) Miyamoto Y, Matsuyama T, Goto T, Ohbe H, Kitamura T, Yasunaga H, Ohta B.
Association between age and neurological outcomes in out-of-hospital cardiac arrest
patients resuscitated with extracorporeal cardiopulmonary resuscitation: a nationwide
multicentre observational study. European Heart Journal: Acute Cardiovascular Care
2021;11(1):35-42. IF4.1 10.1093/ehjacc/zuab021
15) Nishikimi M, Ogura T, Nishida K, Hayashida K, Emoto R, Matsui S, Matsuda
N, Iwami T. Outcome related to level of targeted temperature management in postcardiac
arrest syndrome of low, moderate, and high severities. Critical Care Medicine
2021:49(8):e741-e750. IF8.8 10.1097/CCM.0000000000005025
16) Watanabe M, Matsuyama T, Hikaru O, Sasaki M, Nakamura Y, Miyamoto Y, Okada
N, Kitamura T, Ohta B. Impact of cooling method on the outcome of initial shockable or
non-shockable out of hospital cardiac arrest patients receiving target temperature
management: a nationwide multicentre prospective cohort study. Annals of Intensive
Care 2021;11:163. IF8.1 10.1186/s13613-021-00953-y
17) Shinohara M, Muguruma T, Toida C, Gakumazawa M, Abe T, Takeuchi T. Daytime
admission is associated with higher 1-month survival for pediatric out-of-hospital cardiac
arrest: Analysis of a nationwide multicenter observational study in Japan. PLOS ONE 2021;16:2: IF3.7 10.1371/journal.pone.0246896
18) Shida H, Matsuyama M, Komukai S, Irisawa T, Yamada T, Yoshiya K, Park C,
Nishimura T, Ishibe T, Yagi Y, Kiguchi T, Kishimoto M, Kim SH, Hayashi Y, Sogabe T,
Morooka T, Sakamoto H, Suzuki K, Nakamura F, Nishioka N, Okada Y, Matsui S,
Yoshimura S, Kimata S, Kawai S, Makino Y, Iwami T, Kitamura T, on behalf of the
CRITICAL Study Group Investigators. Early prognostic impact of serum sodium level
among out-of-hospital cardiac arrest patients: A nationwide multicentre observational
study in Japan (the JAAM-OHCA registry). Heart and Vessels 2022:37(7):1255-1264.
IF1.5 10.1007/s00380-022-02020-3
19) Fukushima K, Aoki M, Nakajima J, Aramaki Y, Ichikawa Y, Isshiki Y, Sawada
Y, Oshima K. Favorable prognosis by extracorporeal cardiopulmonary resuscitation for
subsequent shockable rhythm patients, The American Journal of Emergency Medicine
2022:53(3):144-149. IF3.6 10.1016/j.ajem.2022.01.006
20) Naito H, Nojima T, Yorifuji T, Fujisaki N, Nakao A. Mid-term (30- to 90-day)
neurological changes in out-of-hospital cardiac arrest patients: A nationwide retrospective
study (the JAAM-OHCA registry). The American Journal of Emergency Medicine
2022;58(8):27-32. IF3.7 10.1016/j.ajem.2022.05.017
21) Nishihara M, Hiasa K, Enzan N, Ichimura K, Iyonaga T, Shono Y, Kashiura
M, Moriya T, Kitazono T, Tsutsui H. Hyperoxemia is associated with poor neurological
outcomes in patients with out-of-hospital cardiac arrest rescued by extracorporeal
cardiopulmonary resuscitation: insight from the nationwide multicenter observational
JAAM-OHCA (Japan Association for Acute Medicine) Registry. The Journal of
Emergency Medicine 2022;63(2):221-231. IF1.5 10.1016/j.jemermed.2022.05.018
22) Izawa J, Komukai S, Nishioka N, Kiguchi T, Kitamura T, Iwami T. Outcomes
associated with intra-arrest hyperoxemia in out-of-hospital cardiac arrest: A registry-
based cohort study. Resuscitation 2022;181(12):173-181. IF6.5
10.1016/j.resuscitation.2022.11.008
23) Matsui S, Hirayama A, Kitamura T, Sobue T, Hayashi T, Takei H, Tanizawa N,
Ohnishi Y, Kuratani S, Sameshima T, Yoshino G, Kurosawa H, Tanaka R. Target
temperature management and survival with favorable neurological outcome after out-of-hospital cardiac arrest in children: a nationwide multicenter, prospective study in Japan.
Therapeutic Hypothermia and Temperature Management 2022:12(1):16-23. IF1.2
10.1089/ther.2020.0050
24) Kawakami S, Tahara Y, Koga H, Noguchi T, Inoue S, Yasuda S. The association
between time to extracorporeal cardiopulmonary resuscitation and outcome in patients
with out-of-hospital cardiac arrest. European Heart Journal. Acute Cardiovascular Care
2022:11(4):279-289. IF4.1 10.1093/ehjacc/zuac010
25) Enzan N, Hiasa K, Ichimura K, Nishihara M, Iyonaga T, Shono Y, Tohyama
T, Funakoshi K, Kitazono T, Tsutsui H. Delayed administration of epinephrine is
associated with worse neurological outcomes in patients with out-of-hospital cardiac
arrest and initial pulseless electrical activity: insight from the nationwide multicentre
observational JAAM-OHCA (Japan Association for Acute Medicine) registry, European
Heart Journal. Acute Cardiovascular Care 2022;11(5):389-396. IF4.1
10.1093/ehjacc/zuac026
26) Matsuyama T, Ohta B, Kiyohara K, Kitamura T. Intra-arrest partial carbon dioxide
level and favorable neurological outcome after out-of-hospital cardiac arrest: A
nationwide multicenter observational study in Japan (the JAAM-OHCA Registry).
European Heart Journal: Acute Cardiovascular Care 2022;12(1):14-21. IF4.1
10.1093/ehjacc/zuac152
27) Emoto R, Nishikimi M, Shoaib M, Hayashida K, Nishida K, Kikutani K, Ohshimo
S, Matsui S, Shime N, Iwami T. Prediction of prehospital change of the cardiac rhythm
from nonshockable to shockable in out‐of‐hospital patients with cardiac qrrest: A post hoc
analysis of a nationwide, multicenter, prospective registry. Journal of the American Heart
Association 2022;11(12):e025048. IF5.4 10.1161/JAHA.121.025048
28) Kashiura M, Yasuda H, Kishihara Y, Tominaga K, Nishihara M, Hiasa K, Tsutsui
H, Moriya T. Association between short-term neurological outcomes and extreme
hyperoxia in patients with out-of-hospital cardiac arrest who underwent extracorporeal
cardiopulmonary resuscitation: a retrospective observational study from a multicenter
registry. BMC Cardiovascular Disorders 2022;22:163. IF2.1 10.1186/s12872-022-
02598-6
29) Tsuchida T, Ono K, Maekawa K, Hayamizu M, Hayakawa M. Effect of annual
hospital admissions of out-of-hospital cardiac arrest patients on prognosis following
cardiac arrest. BMC Emergency Medicine 2022:22:125. IF2.5 10.1186/s12873-022-
00685-7
30) Funakoshi H, Aso S, Homma Y, Onodera R, TaharaY. Nifekalant versus amiodarone
for out-of-hospital cardiac arrest with refractory shockable rhythms; a post hoc analysis.
Arch Acad Emerg Med 2022;10(1):e6. IF5.4 10.22037/aaem.v10i1.1425
31) Matsuyama M, Ohta B, Kiyohara K, Kitamura T. Cardiopulmonary
resuscitation duration and favorable neurological outcome after out-of-hospital
cardiac arrest: a nationwide multicenter observational study in Japan (the JAAM-
OHCA registry). Critical Care 2022;26:120. IF15.1 10.1186/s13054-022-03994-2
32) Watanabe M, Matsuyama T, Miyamoto Y, Kitamura T, Komukai S, Ota B. The
impact of different targeted temperatures on out of hospital cardiac arrest outcomes
in patients receiving extracorporeal membrane oxygenation: a nation-wide cohort
study. Critical Care 2022;26:380. IF15.1 10.1186/s13054-022-04256-x
33) Sakurai T, Kaneko T, Yamada S, Takahashi T. Extracorporeal cardiopulmonary
resuscitation with temperature management could improve the neurological outcomes of
out-of-hospital cardiac arrest: a retrospective analysis of a nationwide multicenter
observational study in Japan. J Intensive Care 2022;10:30 (2022). IF7.1 10.1186/s40560-
022-00622-7
34) Okada N, Matsuyama M, Okada Y, Okada A, Kandori K, Nakajima S, Kitamura T,
Ohta B. Post-resuscitation partial pressure of arterial carbon dioxide and outcome in
patients with out-of-hospital cardiac arrest: a multicenter retrospective cohort study.
Journal of Clinical Medicine 2022;11(6):1523. IF3.9 10.3390/jcm11061523
35) Nakajima S, Okada N, Kandori K, Okada A, Okada Y, Kitamura T, Ohta B. Targeted
temperature management on outcome of older adult patients after out-of-hospital cardiac
arrest. The American Journal of Emergency Medicine 2023;66:61-66. IF3.7
10.1016/j.ajem.2023.01.027
36) Nakajima S, Matsuyama T, Watanabe M, Komukai S, Kandori K, Okada A, Okada Y, Kitamura T, Ohta B. Prehospital physician presence for patients with out-of-hospital
cardiac arrest undergoing extracorporeal cardiopulmonary resuscitation: a multicenter,
retrospective, nationwide observational study in Japan (the JAAM–OHCA registry).
Current Problems in Cardiology 2023;48(5):101600. IF4.2
10.1016/j.cpcardiol.2023.101600
37) Hatakeyama T, Kiguchi T, Sera T, Nachi S, Urushibata N, Ochiai K, Kitamura T,
Ogura S, Otomo Y, Iwami T. Prehospital airway management and neurological status of
patients with cardiac arrest: a retrospective cohort study. Resuscitation Plus
2023;15(9):100422. IF2.4 10.1016/j.resplu.2023.100422
38) Makino Y, Okada Y, Irisawa T, Yamada T, Yoshiya K, Park C, Nishimura T, Ishibe
T, Kobata H, Kiguchi T, Kishimoto M, Kim SH, Ito Y, Sogabe T, Morooka T, Sakamoto
H, Suzuki K, Onoe A, Matsuyama T, Matsui M, Nishioka N, Yoshimura S, Kimata S,
Kawai S, Zha L, Kiyohara K, Kitamura T, Iwami T. External validation of TiPS65 score
for predicting good neurological outcomes in patients with out-of-hospital cardiac arrest
treated with extracorporeal cardiopulmonary resuscitation. Resuscitation
2022;182(1):109625. IF6.5 10.1016/j.resuscitation.2022.11.018
39) Kashiura M, Kishihara Y, Ozawa H, Amagasa S, Yasuda H, Moriya T. Intra-aortic
balloon pump use in out-of-hospital cardiac arrest patients who underwent extracorporeal
cardiopulmonary resuscitation. Resuscitation 2023;182:109660. IF6.5
10.1016/j.resuscitation.2022.11.026
40) Obara T, Yumoto T, Nojima T, Hongo T, Tsukahara K, Matsumoto N, Yorifuji
T, Nakao A, Elmer J, Naito H. Association of prehospital physician presence during
pediatric out-of-hospital cardiac arrest with neurologic outcomes. Pediatric Critical Care
Medicine 2023;24(5):e244-e252. IF4.1 10.1097/PCC.0000000000003206
41) Okada A, Okada Y, Kandori K, Nakajima S, Matsuyama T, Kitamura T, Ong MEH,
Narumiya H, Iizuka R. Application of the TiPS65 score for out-of-hospital cardiac arrest
patients with non-shockable rhythm treated with ECPR. Resuscitation Plus
2023;16(12):100458. IF2.4 10.1016/j.resplu.2023.100458
42) Matsui S, Kurosawa H, Hayashi T, Takei H, Tanizawa N, Ohnishi Y, Murata S,
Ohnishi M, Yoshii T, Miyawaki K, Matsumoto T, Tanaka R, Kiyohara K, Zha L, Kitamura T, Sobue T, Nitta M. Annual patterns in the outcomes and post-arrest care for pediatric
out-of-hospital cardiac arrest: a nationwide multicenter prospective registry in Japan.
Resuscitation 2023 (E-pub ahead of print). IF6.5 10.1016/j.resuscitation.2023.109942
43) Yoshimura S, Kiguchi T, Irisawa T, Yamada T, Yoshiya K, Park C, Nishimura T, Ishibe T, Kobata H, Kishimoto M, Kim SH, Ito Y, Sogabe T, Morooka T, Sakamoto H, Suzuki K, Onoe A, Matsuyama T, Matsui S, Nishioka N, Okada Y, Makino Y, Kimata S, Kawai S, Zha L, Kiyohara K, Kitamura T, Iwami T. Intra-aortic balloon pump among shockable out-of-hospital cardiac arrest patients: A propensity-weighted analysis in a multicenter, nationwide observational study in Japan (the JAAM-OHCA registry). Journal of Clinical Medicine 2023;12(18):5945. IF3.9 10.3390/jcm12185945
44) Nakayama R, Bunya N, Uemura S, Sawamoto K, Narimatsu E. Prehospital advanced airway management and ventilation for out-of-hospital cardiac arrest with prehospital return of spontaneous circulation: a prospective observational cohort study in Japan. Prehosp Emerg Care 202 (E-pub ahead of print). IF2.4 10.1080/10903127.2023.2260479
45) Inoue T, Kaneda K, Ise N, Koga Y, Yagi T, Todani M, Nakahara T, Fujita M, Tsuruta R. Effects of cardiopulmonary resuscitation instructions on the outcomes of out-of-hospital cardiac arrest: An analysis of the JAAM-OHCA registry. Acute Medicine & Surgery 2023;10(1):e892. IF1.6 doi: 10.1002/ams2.892.
46) Shinada K, Matsuoka A, Koami H, Sakamoto Y. Bayesian network predicted variables for good neurological outcomes in patients with out-of-hospital cardiac arrest. PLoS One 2023;18(9):e0291258. IF3.7 doi: 10.1371/journal.pone.0291258.
47) Shin M, Fujita M, Hifumi T, Koga Y, Yagi T, Nakahara T, Todani M, Kaneda K, Tsuruta R. Rapid rewarming rate associated with favorable neurological outcomes in patients with post-cardiac arrest syndrome patients treated with targeted temperature management. Acute Medicine & Surgery 2023;10(1):e897. IF1.6 doi: 10.1002/ams2.897
48) Okada Y, Komukai S, Irisawa T, Yamada T, Yoshiya K, Park C, Nishimura T, Ishibe T, Kobata H, Kiguchi T, Kishimoto M, Kim SH, Ito Y, Sogabe T, Morooka T, Sakamoto H, Suzuki K, Onoe A, Matsuyama T, Nishioka N, Matsui S, Yoshimura S, Kimata S, Kawai S, Makino Y, Kiyohara K, Zha L, Ong MEH, Iwami T, Kitamura T. Extracorporeal cardiopulmonary resuscitation for patients with out-of-hospital cardiac arrest: an analysis by time-dependent propensity score matching using a nationwide database in Japan. Critical Care 2023;27:442. IF15.1 doi: 10.1186/s13054-023-04732-y
49) Hosomi S, Irisawa T, Nakao S, Zha L, Kiyohara K, Kitamura T, Ogura H, Oda J. Association of sex with post-arrest care and outcomes after out-ofhospital cardiac arrest of initial shockable rhythm: a nationwide cohort study. Frontiers in Cardiovascular Medicine 2023 (E-pub ahead of print). IF3.6 doi: 10.3389/fcvm.2023.1269199
50) Taira T, Inoue A, Kuroda Y, Oosuki G, Suga M, Nishimura T, Ijuin S, Ishihara S. The association between blood glucose levels on arrival at the hospital and patient outcomes after out-of-hospital cardiac arrest: A multicenter cohort study. The American Journal of Emergency Medicine (E-pub ahead of print). IF3.6 doi: 10.1016/j.ajem.2023.12.004
51) Bunya N, Ohnishi H, Igarashi Y, Norii T, Katayama Y, Kasai T, Sawamoto K, Narimatsu E. Effect of prehospital advanced airway management on out-of-hospital cardiac arrest due to asphyxia: A JAAM-OHCA registry-based observational study in Japan. Acute Medicine & Surgery 2023;10(1):e912. IF1.6 doi: 10.1002/ams2.912
52) Nakajima S, Matsuyama T, Kandori K, Okada A, Okada Y, Kitamura T, Ohta B. Impact of time to revascularization on outcomes in patients after out-of-hospital cardiac arrest with STEMI. The American Journal of Emergency Medicine 2024 (E-pub ahead of print). IF3.6 doi: 10.1016/j.ajem.2024.02.030
53) Kandori K, Okada A, Nakajima S, Matsuyama T, Kitamura T, Narumiya H, Iizuka R, Hitosugi M, Okada Y. Association between eGFR and neurological outcomes among patients with out-of-hospital cardiac arrest: A nationwide prospective study in Japan. Acute Medicine & Surgery 2024;11(1):e952. 10.1002/ams2.952
54) Nishioka N, Yamada T, Nakao S, Yoshiya K, Park C, Nishimura T, Ishibe T, Yamakawa K, Kiguchi T, Kishimoto M, Ninomiya K, Ito Y, Sogabe T, Morooka T, Sakamoto H, Hironaka Y, Onoe A, Matsuyama T, Okada Y, Matsui S, Yoshimura S, Kimata S, Kawai S, Makino Y, Zha L, Kiyohara K, Kitamura T, Iwami T, on behalf of the CRITICAL Study Group Investigators. External validation of updated prediction models for neurological outcomes at 90 days in patients with out-of-hospital cardiac arrest. Journal of the American Heart Association 2024;0:e033824. 10.1161/JAHA.123.033824
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68) Sakamoto K, Yasuda H, Shinzato Y, Kishihara Y, Amagasa S, Kashiura M, Moriya T. Optimal timing for epinephrine administration in adult patients with out-of-hospital cardiac arrest: A retrospective observational study. Academic Emergency Medicine 2025 (E-pub ahead of print). 10.1111/acem.15089
69) Izawa J, Kimata S, Komukai S, Okubo M, Sakai A, Kitamura T, Yamaguchi Y. High normocapnia and better functional outcome in patients undergoing veno-arterial extracorporeal membrane oxygenation after out-of-hospital cardiac arrest. CHEST 2025 (E-pub ahead of print). 10.1016/j.chest.2025.01.010
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